Seneca Communities

Getting To Know Seneca

Seneca is a city in Oconee CountySouth Carolina, United States. The population was 8,102 at the 2010 census. It is the principal city of the Seneca Micropolitan Statistical Area (population 74,273 at the 2010 census), an (MSA) that includes all of Oconee County, and that is included within the greater Greenville-Spartanburg-Anderson, South Carolina Combined Statistical Area (population 1,266,995 at the 2010 census). Seneca was named for the nearby Cherokee town of Isunigu, which English colonists knew as "Seneca Town".